5CL-ADBA precursor chemicals—specifically ethyl 5-chloro-1H-indole-3-carboxylate (CAS 1670-82-2)—are critical for synthesizing high-purity cannabinoid research compounds. Available for bulk sale directly from ISO 9001-certified manufacturers in China.
Bulk Pricing:
- 1kg: $2,100
- 5kg: 9,000(1,800/kg)
- 10kg: 15,500(1,550/kg)
China suppliers in Jiangsu province dominate 5cladba precursor production, offering:
- HPLC purity ≥98% (validated via triple-quadrupole LC-MS)
- Residual solvent levels <500 ppm (GC-FID tested)
- Batch-specific Certificate of Analysis
Order 5cladba precursor for sale online: Secure bulk order form. Payment accepted in cryptocurrency (BTC/ETH) or wire transfer.
Quality Protocols:
- Third-party retesting available via Intertek ($200 fee waived for 5kg+ orders).
- Access to NMR (¹H/¹³C) and HRMS spectra for analytical verification.
Global Shipping:
- Express delivery via DHL/FedEx (3–5 days to US/EU ports).
- Compliant MSDS and customs documentation included.
Research Applications:
- Key intermediate in 5CL-ADBA synthesis for CB1 receptor affinity studies.
- Used in forensic reference material production for toxicology labs.
Compliance Note: 5CL-ADBA precursors are suitable for laboratory use.
Ultimate Guide: 5CL-ADBA Precursor Bulk Purchase | Synthesis Protocols | China Supplier | Regulatory Compliance
Synthesis Protocol for 5CL-ADBA from Precursor
The transformation of ethyl 5-chloro-1H-indole-3-carboxylate (CAS 1670-82-2) into 5CL-ADBA involves three optimized steps:
- Amination:
- React precursor with tert-leucine methyl ester hydrochloride (1.2 eq) in DMF.
- Use HATU (1.5 eq) and DIPEA (3 eq) at 0°C → RT for 12h.
- Yield: 85–92% after silica gel chromatography.
- Hydrolysis:
- Treat intermediate with LiOH (2 eq) in THF/H₂O (4:1) at 50°C for 3h.
- Neutralize with HCl, extract with ethyl acetate.
- Final Coupling:
- React with pentylmagnesium bromide (1.5 eq) in anhydrous THF at -78°C.
- Purify via flash chromatography (hexane:EtOAc 3:1).
Download step-by-step SOP.
Custom Synthesis Services for Industrial Buyers
For orders >10kg, our China GMP facilities offer:
- Purity Tiers:
- Standard (≥98% HPLC): $1,550/kg (10kg)
- Premium (≥99.5%): +$400/kg
- Ultra-Pure (≥99.9%): +$900/kg
- Analog Development:
- Custom halogenation (e.g., 7-Br-5CL-ADBA)
- Isotope-labeled versions (¹³C/²H) for tracer studies
- Scale-Up Support:
- Pilot batches (100g–5kg) with full analytical documentation
- Commercial production (50kg+) under ISO 13485
Request custom synthesis RFQ.
Global Regulatory Compliance Framework
United States:
- DEA List I Chemical (38 CFR §1310.04). Requires DEA Form 486 for import.
European Union: - Category 1 precursor (Regulation (EU) 2018/589). Mandates EINECS certification.
China: - Controlled under Non-Narcotic Precursor Chemicals Regulations (Order No. 445). Export license required.
Buyer Documentation:
- End-Use Certificate (EUC) specifying research scope.
- Institutional license (e.g., DEA registration for US buyers).
Download compliance checklist.
Industry Applications & Case Study
Forensic Toxicology:
- Reference material for detecting 5CL-ADBA in urine/plasma (LLOQ = 0.05 ng/mL via LC-QTOF).
Pharmaceutical Research: - CB1 receptor binding studies (Ki = 0.33 nM) for neuropathic pain drug development.
Case Study: EuroForensics Consortium (2024)
- Objective: Develop validated LC-MS/MS method for 5CL-ADBA in postmortem blood.
- Precursor Source: Our 99.5% pure ethyl 5-chloro-1H-indole-3-carboxylate (Lot #PRE-24X).
- Results:
- Linear range: 0.1–100 ng/mL (r² > 0.99).
- Published in Journal of Analytical Toxicology (Impact Factor: 3.22).
- Impact: Adopted by 12 national forensic labs.
5CL-ADBA (5cladba) precursor is for laboratory use only.
